Which adverse reaction is associated with Angiotensin II Receptor Blockers (ARBs) such as losartan?

Which adverse reaction is associated with Angiotensin II Receptor Blockers (ARBs) such as losartan?

• A. Hyperkalemia
• B. Hypoglycemia
• C. Life-threatening renal dysfunction
• D. Orthostatic hypotension

Answer: (D)

Angiotensin II receptor blockers reduce the effects of angiotensin II, leading to vasodilation and lower aldosterone levels. This lowers blood pressure and can cause dizziness, especially when standing. Orthostatic hypotension is a recognizable reaction because standing up can reveal a drop in blood pressure as the body’s compensatory mechanisms aren’t fully countering the drug’s vasodilatory effect. While hyperkalemia is also a known risk with ARBs due to reduced aldosterone, the specific postural drop in blood pressure fits the described adverse reaction most directly. Start with cautious dosing and monitor for lightheadedness or faintness when standing, particularly in older patients or those also taking diuretics.

Angiotensin II receptor blockers reduce the effects of angiotensin II, leading to vasodilation and lower aldosterone levels. This lowers blood pressure and can cause dizziness, especially when standing. Orthostatic hypotension is a recognizable reaction because standing up can reveal a drop in blood pressure as the body’s compensatory mechanisms aren’t fully countering the drug’s vasodilatory effect. While hyperkalemia is also a known risk with ARBs due to reduced aldosterone, the specific postural drop in blood pressure fits the described adverse reaction most directly. Start with cautious dosing and monitor for lightheadedness or faintness when standing, particularly in older patients or those also taking diuretics.