Which statement about ARBs is true?

Which statement about ARBs is true?

• A. They increase aldosterone release
• B. They block angiotensin II receptors leading to vasodilation
• C. They are safe in pregnancy
• D. They require combination with ACE inhibitors

Answer: (B)

Blocking the AT1 receptor for angiotensin II prevents angiotensin II from causing vasoconstriction and stimulating aldosterone release. The net effect is dilation of systemic arterioles and reduced aldosterone-mediated sodium and water retention, which lowers blood pressure. This direct mechanism is why this statement is true. Although renin and angiotensin II levels rise when ARBs are used, the blocked receptor means aldosterone release is not enhanced. ARBs are not safe in pregnancy due to risk of fetal renal injury, and they’re not recommended to be used with ACE inhibitors because combining them raises the risk of hyperkalemia and kidney problems.